The physiological or pathophysiological relevance of an extracellular histone-mediated blockade of CCK- and ACh-induced calcium oscillations in isolated rat pancreatic acini, and of extracellular histone-triggered calcium oscillations in cultured AR4-2J, observed in the present work, may be corroborated by circulating concentrations of histones found in patients with severe acute pancreatitis, sepsis, sterile inflammation or trauma, as mentioned before [15,16,18,20,21,22]. The gene discussed is CCK; the disease is Sepsis.