In fact, the NOD-like receptor family pyrin containing 3 (NLRP3) inflammasome has been associated with the development of NASH and palmitic acid increases the expression of NLRP3 inflammation and induces IL-1b e TNF—a secretion in liver favoring the progression of NAFLD [34]. This evidence concerns the gene NLRP3 and metabolic dysfunction-associated steatotic liver disease.