Geldanamycin, a HSP90 inhibitor, alters the physical association of mutp53 with the HSP90 complex, leading to reduced protein half-life of several TP53 mutants via ubiquitination and proteasomal degradation, in multiple cancer cell lines, including T47D (L194F), MDA-MB-468 (R273H), and SKBR3 (R175H) [149,150,151]. This evidence concerns the gene TP53 and cancer.