TP53 and central nervous system cancer: In multiple glioma and breast cancer cells carrying mutp53, including U373 (R273H), T47D (L194F), SKBR3 (R175H), and BT474 (E285K), overexpression of Tid/DNAJA3 restores mitochondrial localization and pro-apoptotic activities of TP53 when these cells are treated with DFX [99].