MDM2 and cancer: Moreover, Li et al. [94] demonstrate that HSP90 forms a complex with mutp53 to prevent mutp53’s aggregation by inhibiting the E3 ligase activity of MDM2 and CHIP in multiple cancer cells, including MDA-MB-468 (R273H), MDA-MB-231 (R280K), DU145 (P223L/V274F), T47D (L194F), SW480 (R273H/P309S), SKBR3 (R175H), and 5637 (R280T).