In addition to that we have confirmed the involvement of specific proteins previously associated with ALS as LGALS3 and TTR, S100A6, S100A11, and have observed the involvement of other new proteins involved in ALS not previously described as SELENBP1, PIN-1, CACYBP and ROCK2. Additional targeted experiments are needed to functionally evaluate the role of this protein panel in tardopathies. Here, CACYBP is linked to amyotrophic lateral sclerosis.