SOD1 and amyotrophic lateral sclerosis: There are little evidence of Rho kinases being linked to ASL; however Rho kinase inhibition has been described to have a neuroprotective effect in a SOD1 (G93A) mouse model of ALS [63] and abnormal expression of ROCK2 has been associated with high levels of myosin binding protein H expression in ALS [64], making these two candidates new possible candidates for future study and additional exploration.