Four more proteins, Peptidyl-prolyl cis/trans isomerase (PIN-1), Selenium-binding protein 1 (SELENBP1), Calcyclin-binding protein (CACYBP) and Rho-associated protein kinase 2 (ROCK 2) (Figure 2), were selected as well to be retested, due to their potential novel role in ALS. The gene discussed is PIN1; the disease is amyotrophic lateral sclerosis.