Among the candidates, proteins well characterized and widely described to be altered in ALS in previous studies, like Galectin-3 (LGALS3) Prealbumin (TTR) Protein S100-A6 (S100A6) and Protein S100-A11 (A100A11) were selected in order to reinforce the existing knowledge and literature related to them [32,34,46,47,48]. Here, S100A6 is linked to amyotrophic lateral sclerosis.