Both PHB1 and 2 were down-regulated across the two diseases in spinal cord, with a stronger down-regulation of PHB2. Interestingly, only for FTLD both PHB1 and PHB2 were found significantly dysregulated when analyzing NMC samples with a non-significant trend to down-regulation in ALS (Figure 6). The gene discussed is PHB2; the disease is amyotrophic lateral sclerosis.