Patients with upper UTI had higher C-reactive protein (CRP) levels (6.9 [0.8–28.7] vs. 2.7 [1.0–8.1] mg/dL; P = 0.0015) and longer duration of fever before admission (2 [1–8] vs. 1 [1–3] days; P = 0.06) compared with those with lower UTI (Table 2). The gene discussed is CRP; the disease is bacterial urinary tract infection.