Recently, in a murine model of Alzheimer’s disease, AT-LXA4 and RvE1 were endogenously produced via sphingosine kinase 1 (SphK1)-dependent acetylation of cyclooxygenase (COX)-2 and reduced disease pathology via enhancement of microglial phagocytosis31. The gene discussed is SPHK1; the disease is Alzheimer disease.