Recently, in a murine model of Alzheimer’s disease, AT-LXA4 and RvE1 were endogenously produced via sphingosine kinase 1 (SphK1)-dependent acetylation of cyclooxygenase (COX)-2 and reduced disease pathology via enhancement of microglial phagocytosis31. Here, SPHK1 is linked to early-onset autosomal dominant Alzheimer disease.