Patients with intraoperative hyponatremia (<130 mEq/L, n = 338, 29.0%) had frequent diabetes mellitus, frequent alcoholic liver cirrhosis, lower preoperative hemoglobin level, lower albumin level, higher MELD score, higher Child classification, longer cold ischemic time, frequent red blood cell and fresh frozen plasma transfusion than those with mean serum sodium between 130 and 145 mEq/L. The gene discussed is ALB; the disease is Hyponatremia.