Given (i) the fact that both PAX2 and MYC are repressors of HBD1 transcription and (ii) the proximity of their respective DNA recognition binding sites, it would be of interest to decipher their respective role in the suppression of HBD1 expression in colon cancer and whether they act in synergy to dampen HBD1 transcription. This evidence concerns the gene DEFB1 and colonic neoplasm.