TYR and melanoma: These studies are in general agreement that the detection of unique multi-panel biomarkers such as S100B, MAGE-3, p97, MUC-18, S100A4, MART1, HMB45, and tyrosinase, by real-time quantitative PCR (qRT-PCR) in CMCs of melanoma patients can have a valuable prognostic utility, especially in patients with Stage II and III disease10–14.