F2R and melanoma: Additional receptors include the GPCR F2R (also known as PAR-1), which has previously been implicated in melanoma progression59, as well as BRS3, HTR2A, and BDKRB2. Further work will be needed to ensure that the resistance phenotypes observed are in fact due to overexpression of the protein-coding gene, rather than, for example, a nearby non-coding transcript, as well as to understand the resistance mechanisms.