A decreased expression of hsa-miR-150 has been also described in chronic46 and acute47 myeloid malignancies, for example, hsa-miR-150 maturation is inhibited and its expression is down-regulated in acute myeloid leukemias involving the mixed lineage leukemia (MLL) gene47. The gene discussed is KMT2A; the disease is acute myeloid leukemia.