We show for the first time that LRP8 RNA levels were higher in estrogen‐negative breast tumors (TNBC and HER2 [ER−/HER2+] tumors), than in luminal breast tumors (LA [ER+/HER2−] and LB [ER+/HER2+] samples), and that these levels were the highest in TNBC samples, in three different cohorts. The gene discussed is ESR1; the disease is breast neoplasm.