We found that LRP8 was more strongly expressed (at the mRNA level) in breast cancers without hormone receptor expression (TNBC [ER−/PR−/HER2−], ER−/HER2+) than in luminal tumors (luminal A [ER+/HER2−], luminal B [ER+/HER2+]), and normal breast tissues. The gene discussed is ESR1; the disease is breast cancer.