HIF1A and cor pulmonale: For instance, previous studies showed that HIF‐1 plays an important role in critical pathological processes of pulmonary heart disease in patients with hypoxic pulmonary hypertension and COPD (Fan et al., 2011; Manalo et al., 2005; Qian, Wang, Ming, & Liang, 2012; Schultz, Fanburg, & Beasley, 2006; Xie et al., 2017).