NEAT1 and colorectal cancer: NEAT1 has 2 isoforms: 3.7knt NEAT1_1 with poly(A) tail and 23knt NEAT1_2, both of which are crucial components of the paraspeckles.10 NEAT1 is found upregulated in most cancers, and higher expression of NEAT1 relates to poor prognosis in cancer.12 For instance, NEAT1 was identified by Wu et al16 as a diagnostic and prognostic biomarker in colorectal cancer.