ALDH3B2 was widely known as a member of aldehyde dehydrogenases (ALDHs).42 It plays a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation and has been implicated as causes of some cancers and male infertility.43, 44 The last gene GLDC, which encodes glycine decarboxylase. Here, GLDC is linked to male infertility.