It serves as an oncogene that promotes tumorigenesis and cellular transformation.45 Several studies have reported that GLDC was overexpressed in many cancer cell lines, including ovarian, cervical, lung, lymphoma, prostate, and phyllodes cancer cell lines.46, 47 Moreover, Sabina et al48 found that GLDC expression is exploited by malignant tumors for adapting their metabolism under hypoxic conditions, thereby being associated with aggressiveness. This evidence concerns the gene GLDC and cancer.