Of the 101 patients recruited in this study, one or more somatic mutations in the 14 colorectal cancer‐related genes (AKT1, BRAF, CTNNB1, EGFR, ERBB2, FBXW7, GNAS, KRAS, MAP2K1, NRAS, PIK3CA, SMAD4, TP53, and APC) were detected in 88 (87.1%) plasma of patients with mCRC (Figure S1). Here, CTNNB1 is linked to colorectal cancer.