In addition to the TAL1 and ANTP homeobox gene family members, several genes not previously associated with T‐ALL biology were identified among the top most significant DEGs between the CIMP subgroups, including BEX1, PLXND1, PLCB4, and MYO18B (Figure 2C). The gene discussed is PLCB4; the disease is acute lymphoblastic leukemia.