The transcriptome analysis also identified differentially expressed genes between CIMP subgroups that had not been previously linked to T‐ALL biology, including BEX1, PLXND1, PLCB4, and MYO18B. The MYO18B gene has previously been described as a tumor suppressor gene whose expression was shown to be regulated by epigenetic mechanisms in lung,31 ovarian,32 and colorectal cancers.33 Its relevance for hematological malignancies is largely unknown but we have shown dysregulated gene expression of MYO18B in pediatric T‐ALL. Here, PLCB4 is linked to hematologic disorder.