The PLXND1 gene has been implicated in intra‐thymic migration of thymocytes during T‐cell development, is a transcriptional target of the T‐ALL‐associated NOTCH signaling pathway, and has been found to be upregulated in prostate cancer.28, 29PLCB4 has also been associated with various cancers such as gastrointestinal tumors46 and melanoma.30 The BEX family genes, namely BEX1 and BEX2, were significantly upregulated in the CIMP− subgroup, and we showed a negative correlation of promoter DNA methylation with gene expression for both BEX genes in the T‐ALL samples. Here, PLXND1 is linked to acute lymphoblastic leukemia.