Recently, it was also shown that classification based on gene mutations (NOTCH1, FBXW7, PTEN, and Ras) combined with MRD and WBC status improves risk stratification of pediatric T‐ALL patients.56 The next step will be to combine the mutational classification with CIMP subgrouping in larger cohorts, to evaluate the interplay of these prognostic biomarkers and their individual and combined potential to improve therapy stratification of T‐ALL. Here, NOTCH1 is linked to acute lymphoblastic leukemia.