In both models, ITPP monotherapy did not affect tumour growth, as the times to reach the end‐point were 8.80 ± 0.42 days (n = 6) and 8.90 ± 0.35 days (n = 6) for the treated and untreated rhadomyosarcomas, 15.00 ± 0.53 days (n = 8) and 14.61 ± 0.71 days (n = 8) for the treated and untreated 9L‐gliomas respectively. Here, TPP1 is linked to central nervous system cancer.