However, Embury et al. (2017) have conversely reported that the overexpression of CatB in hippocampal neurons using adeno‐associated virus serotype 2/1 ameliorates Alzheimer's disease‐like pathologies, including β‐amyloidosis and impairments in learning and memory in the mouse brain. This evidence concerns the gene TYRP1 and early-onset autosomal dominant Alzheimer disease.