Interestingly, Lambrechts et al16 identified a cluster (fibroblast 2) expressing αSMA and MYH11, displaying myogenic properties, similar to pCAF subtype B. Podoplanin‐positive CAFs have been previously associated with poor prognosis in several cancers 32, 33, 34, 35, 36, 37. The gene discussed is ACTA1; the disease is cancer.