For example, glaucoma is observed in AGS beyond IFIH1, most commonly in association with SAMHD1-associated disease [12]; arthropathy is a feature of a number of type I interferonopathies including the recently described DNASEII deficiency [13]; finally, we have recently noted early loss of secondary dentition in an adult with a pathogenic homozygous RNASEH2B variant and in several patients with CANDLE (unpublished). Here, SAMHD1 is linked to Aicardi-Goutieres syndrome.