Indeed, hypermethylation of the Wif1 promoter, leading to Wif1 silencing (and thus activation of Wnt/beta-catenin signaling), was shown to be associated with various types of cancers such as lung cancer, in particular non-small cell lung cancer (NSCLC) (Wissmann et al., 2003; Tan et al., 2013; Zheng et al., 2016; Guo et al., 2017), osteosarcoma formation (Kansara et al., 2009), colorectal cancer (Hu et al., 2018), cervical cancer (Ramachandran et al., 2012) and others (Figure 1). Here, WIF1 is linked to lung cancer.