WIF1 and cancer: The epigenetic silencing of secreted Wnt pathway inhibitors related to cancer appears not restricted to Wif1 but holds true also for most other members such as Dkk1-3, Sost, Igfbp4 or sFRP1-5 (Mazieres et al., 2004; Aguilera et al., 2006; Roman-Gomez et al., 2007; Sato et al., 2007; Elston et al., 2008; Kongkham et al., 2010; Fellenberg et al., 2013; Gopal et al., 2013).