In an in vitro leukemia model, two BMI1 inhibitors, PTC-209 and PRT-4165, down-regulating the expression of NOTCH1, HES1, and c-MYC, were able to block the leukemic cells growth, suggesting that the BMI1 inhibitors can be good candidates against leukemia (25). The gene discussed is NOTCH1; the disease is leukemia.