BMI1 and neoplasm: In other neoplasias, such as the breast cancer, the BMI1 knock-down is able to increase the expression of several tumor-suppressive miRNAs (miR-200a, miR-200b, miR-15a, miR-429, miR-203), with the consequent reduced expression of N-Cadherin, Vimentin, and β-Catenin, thus resulting in a decreased invasion, migration and proliferation of the neoplastic cells (24).