According to the amyloid cascade hypothesis of AD, the crucial step towards neurodegeneration is the deposition of insoluble Aβ in plaques in the brain tissue: the hyper-phosphorylation of tau, the formation of NFTs and, more generally, the disease progression is secondary to amyloid deposition, due to the imbalance between amyloid production and clearance [75]. Here, MAPT is linked to Alzheimer disease.