Furthermore, in the present study, IPA revealed that the affected genes associated with cardiovascular disease as one of the main aging-associated diseases; these genes included the genes for many extracellular space protein (DCN, ELN, IGFBP3, POSTN, PTX3, THBS1, and THBS2), which were downregulated in fibroblasts from ARCL2B patients. This evidence concerns the gene IGFBP3 and cardiovascular disorder.