In multivariable models, only current CD4 count of <200 cells/μL (P=0.076) was marginally significantly associated with shorter LTL among the middle-aged HIV-infected participants, whereas depressive symptoms (P=0.026) and insomnia symptoms (P=0.018) were significantly associated with shorter LTL among the old HIV-infected participants when one was included without the other (Table 2). The gene discussed is CD4; the disease is insomnia.