In multivariable models LTL was only marginally significantly associated with a current CD4 count of <200 cells/μL (P=0.069) among all HIV-infected participants in addition to the significant interaction between age and insomnia symptoms as described above (Table 2), whereas LTL was significantly associated with at least a junior middle school education level and depressive symptoms among all HIV-uninfected participants (Table 3). This evidence concerns the gene CD4 and insomnia measurement.