CDH1 and invasive lobular breast carcinoma: Annunziato S et al. reported an intriguing effect of CRISPR machinery delivered via lentiviruses: they described an innovative approach to model invasive lobular breast carcinoma by intraductal injection of lentiviral vectors encoding Cre recombinase, the CRISPR/Cas9 system, or both, in female mice carrying conditional alleles of the Cdh1 gene, encoding for E-Cadherin.