BIRC5 and ovarian carcinoma: Another recent study involving gene editing mediated by lentiviral delivery was made by Zhao G et al. reporting that BIRC5 gene KO inhibited the Epithelial to Mesenchymal Transition (EMT) in ovarian cancer cells by upregulating epithelial cell markers such as cytokeratin 7 and downregulating mesenchymal markers like Snail2, β-Catenin, and Vimentin while overexpression of BIRC5 promoted EMT [25].