While the presence of anti-HLA-C IgG antibodies has been described in women with recurrent miscarriages, the competency of virus-specific CD8+ T cells to cross-react with HLA-C raises the question whether allo-HLA-C IgG antibodies are the only player in recurrent miscarriages or whether decidual virus-specific CD8+ T cells with cross-reactive potential also play their part in pregnancy complications. This evidence concerns the gene HLA-C and spontaneous abortion.