Chimeric proteins could also be used for instance by replacing 11 amino acids of the PRYSPRY domain of the rhesus macaque ortholog into hTRIM5α, which efficiently restricted HIV-1 infection of CCR5- and CXCR4-tropic HIV-1 clones in CD34+ cell-derived macrophages in vitro, and in mouse-derived thymocytes in vivo (256). Here, CCR5 is linked to HIV-1 infection.