FOXO1 and rheumatoid arthritis: We hypothesize that the milieu within the inflamed synovium of RA patients favors the induction of miR-31, on the one hand by a repeated auto-antigenic stimulation inducing the expression of T-bet and IFN-γ, and on the other, by IL-7 expression (73) which represses FOXO1 (48), thereby arresting proinflammatory Th cells in the inflamed tissue, where they receive survival signals that counteract immunosuppressive therapies and promote inflammation (4).