Then the ARVC-related four key biological pathways (cytokine–cytokine receptor interaction, chemokine signaling pathway, JAK-STAT signaling pathway, and neuroactive ligand–receptor interaction) and four hub genes (CXCL2, TNFRSF11B, LIFR, and C5AR1) in ARVC samples were identified by GSNCA method. The gene discussed is LIFR; the disease is Arrhythmogenic right ventricular dysplasia.