Then the ARVC-related four key biological pathways (cytokine–cytokine receptor interaction, chemokine signaling pathway, JAK-STAT signaling pathway, and neuroactive ligand–receptor interaction) and four hub genes (CXCL2, TNFRSF11B, LIFR, and C5AR1) in ARVC samples were identified by GSNCA method. Here, CXCL2 is linked to Arrhythmogenic right ventricular dysplasia.