In addition, the four hub genes (CXCL2, TNFRSF11B, LIFR, and C5AR1) with a high correlations (|r| > 0.6, Table 1) were associated with these above four vital signaling pathways in ARVC samples (Figure 7). The gene discussed is TNFRSF11B; the disease is Arrhythmogenic right ventricular dysplasia.