Then the ARVC-related four key biological pathways (cytokine–cytokine receptor interaction, chemokine signaling pathway, JAK-STAT signaling pathway, and neuroactive ligand–receptor interaction) and four hub genes (CXCL2, TNFRSF11B, LIFR, and C5AR1) in ARVC samples were identified by GSNCA method. Here, C5AR1 is linked to arrhythmogenic right ventricular cardiomyopathy.