In addition, the four hub genes (CXCL2, TNFRSF11B, LIFR, and C5AR1) with a high correlations (|r| > 0.6, Table 1) were associated with these above four vital signaling pathways in ARVC samples (Figure 7). Here, C5AR1 is linked to arrhythmogenic right ventricular cardiomyopathy.