As we described earlier, after combined WGCNA and GSNCA test analysis filtering, the four key pathways and four genes (CXCL2, TNFRSF11B, LIFR, and C5AR1) in ARVC samples were identified, and they were entered t-tests subsequently, and their results showed significant differences (all p < 0.05, Figure 8A) between two groups. The gene discussed is C5AR1; the disease is Arrhythmogenic right ventricular dysplasia.