TNFRSF11B is member 11B, tumor necrosis factor receptor superfamily, expressed within lymphoid cells as well as up-regulated by the stimulation of CD40, involved within the osteoclastogenesis, it is recognized as one candidate cardiovascular disease gene by human protein atlas, and it might also work in arterial calcification prevention (Harper et al., 2016). Here, CD40 is linked to cardiovascular disorder.