In addition to TGF-β1, some members of the mitogen-activated protein kinase (MAPK) family and protein kinase B (Akt)/glycogen synthase kinase-3β (GSK-3β) signaling, are also involved in myocardial fibrosis (Ying et al., 2017; Yue et al., 2017). The gene discussed is AKT1; the disease is Myocardial fibrosis.