Furthermore, some of these proteins act as tumor suppressors (e.g., TMEM25, TMEM7) (Zhou et al., 2007; Doolan et al., 2009) while others act as pro-oncogenes (e.g., TMEM158, TMEM14A...) (Cheng et al., 2015; Zhang et al., 2016). Here, TMEM158 is linked to neoplasm.