Wang et al. analyzed the methylation profile of TMEM176A promoter in 13 cell lines (BIC1, TE1, TE3, TE13, KYSE140, KYSE180, KYSE410, KYSE450, KYSE520, Segl, KYSE150, YES2, and COLO680N) and 267 primary esophageal squamous cell carcinoma. The gene discussed is TMEM176A; the disease is esophageal squamous cell carcinoma.