MAPT and Alzheimer disease: Previous studies have described that i.c.v. injections of synaptotoxic AβOs cause deleterious effects on rat performance in different memory tasks and reproduce several AD pathological hallmarks – including gliosis, tau protein hyperphosphorylation and synapse loss (Townsend et al., 2006; Poling et al., 2008; Balducci et al., 2010; Dineley et al., 2010; Alberdi et al., 2013; Figueiredo et al., 2013; Lourenco et al., 2013; Forny-Germano et al., 2014; Brkic et al., 2015; Faucher et al., 2015; Ahmad et al., 2017).