PSEN1 and memory impairment: In transgenic APP/PS1 mice, NAC administration prevents passive avoidance memory impairment, suppresses brain protein oxidation and S-nitrosylation (Huang et al., 2010), decreases Aβ-40 and Aβ-42 hippocampal levels and restores contextual fear memory and hippocampal LTP (Hsiao et al., 2012).