Interestingly, mutations in SPG11 encoding spatacsin, were also found in other motor neuron diseases such as AR juvenile-onset amyotrophic lateral sclerosis (ALS5) and AR Charcot-Marie-Tooth disease (Montecchiani et al., 2016; Orlacchio et al., 2016). Here, SPG11 is linked to Charcot-Marie-Tooth disease.