Interestingly, mutations in SPG11 encoding spatacsin, were also found in other motor neuron diseases such as AR juvenile-onset amyotrophic lateral sclerosis (ALS5) and AR Charcot-Marie-Tooth disease (Montecchiani et al., 2016; Orlacchio et al., 2016). The gene discussed is SPG11; the disease is amyotrophic lateral sclerosis type 5.