This result may arise from the vast heterogeneity and lack of correlation between genotype and phenotype in SPG11. Thus, in addition to HSP type 11, mutations in SPG11 can lead to autosomal recessive juvenile amyotrophic lateral sclerosis and Charcot-Marie-Tooth disease (Montecchiani et al., 2016). The gene discussed is SPG11; the disease is Charcot-Marie-Tooth disease.