It also has been reported that dietary flavonoid nobiletin could induce its own metabolism and in turn enhance its cytostatic effect in MCF7 breast cancer cells, by cytochrome P450-1A1 (CYP1A1) and cytochrome P450-1B1 (CYP1B1) upregulation (12). This evidence concerns the gene CYP1A1 and breast carcinoma.