TP53 and neoplasm: It is obvious that the mechanism of tumor cell apoptosis is mediated by the p38 MAPK signal transduction pathway under the action of different stimuli, including induction of apoptosis through caspase-dependent apoptotic pathways (15), induction of apoptosis by phosphorylation of p53, as well as induction of apoptosis by members of the Bcl-2 protein family (16).