For example, the results from Iwakiri et al. [45] have demonstrated that the significant association between high expression of CXCR7 and poor prognosis of tumor patients existed only in patients with p-stage I NSCLC, not in patients with p-stage II–III NSCLC, because tissues of p-stage II–III NSCLC include both patients exposed to preoperative therapy and not. This evidence concerns the gene ACKR3 and neoplasm.