In bone sarcomas, the binding of CXCL12 to CXCR7 can activate the PI3K-Akt-NF-κΒ and MEK-ERK-IKKαβ-NF-κΒ pathways, which regulates the proliferation/survival as well as the migration/metastasis of tumor cells [60]. This evidence concerns the gene ACKR3 and bone sarcoma.