PML and neoplasm: Under pro-apoptotic conditions, such as cisplatin and UV treatment, YAP is phosphorylated at the Tyr357 residue, which enhances the transcription of pro-apoptotic genes, such as Bax, p53AIP1, PML, and puma; this supports its function as a tumor suppressor [15, 30, 32, 46, 47].