Second, in contrast with our study (Table 2, Fig. 3B), Schistosoma-induced splenomegaly was related to up-regulation of several interferon-inducible genes such as Irf7, Oas2 and Ifit2. Third, Schistosoma-induced splenomegaly showed decreased expression of lymphocyte chemokines (e.g., Cxcl13, Ccl19 and Ccl21)30, while no changes were observed in our study. Here, CCL21 is linked to Splenomegaly.