Combined evidence from our cFos analysis (Fig. 2a), retrograde tracing experiments (Fig., 2c–e), and in vivo electrophysiology (Fig. 3) indicates that IgSF9b deletion normalizes anxiety-related output specifically in the CeM of Nlgn2 x IgSF9b double KO mice. The gene discussed is NLGN2; the disease is Anxiety.