NLGN2 and Anxiety: Interestingly, anxiety levels appeared to be exacerbated in Nlgn2 KO but not in WT mice over the observed 6-week time period, even in mice that had not undergone surgery (Supplementary Fig. 5b-d), and this effect was completely reversed by local reduction of IgSF9b (Fig. 4f–h, Supplementary Fig. 5e-f).