Using this strategy, we identified four novel single-disease genome-wide associations, one for CeD (rs6806528 at FRMD4B), two for SSc (rs4258254 at TNFSF4 and rs17849502 at NCF2), and one for T1D (rs4238595 at UMOD) (Fig. 1, Additional file 2: Figures S6-S8, and Additional file 1: Table S5). This evidence concerns the gene TNFSF4 and systemic sclerosis.