IDH1 and glioblastoma: With regard to the prognostic molecular characterization of GBM, the 2016 World Health Organization (WHO), for the first time, used the isocitrate dehydrogenase (IDH) gene mutation status as the classification molecular parameter to separate the GBM into three groups: GBM IDH-wild type, GBM IDH-mutant, and GBM NOS [37], with different prognosis [38].