MTHFD2 and glioblastoma: To further explore the characteristics of the prognostic PCGs and lncRNAs in the signature, we found EIF2AK3, EPRS, MTHFD2, RNF212, LINC02015, CTD-2140B24.6 were protected factors for GBM patients highly expressed these genes with a long survival time (univariable cox coefficient < 0), and the remaining genes (GALE, GUCY2C, LINC00618, AC068888.1, CERNA1) associated with short survival time were risk factors (univariable cox coefficient > 0) according to the univariable cox result in Table 2.