Interestingly, a similar decrease of plaque-associated microglia, the presence of less compact plaques and higher neuritic dystrophy around plaques has also been observed in AD patients expressing the R47H variant of TREM2 compared to those patients expressing the common TREM2 variant, confirming the partial loss-of-function caused by the R47H variant [136]. The gene discussed is TREM2; the disease is Alzheimer disease.