Conversely, the observation that deletion of TREM2 in APPPS1-21 mice decreased the Aβ burden in 2-months-old animals but resulted in higher Aβ accumulation in the cortex of 8-months-old animals [131] suggests that MGnD could be beneficial in the later stages of amyloid pathology. The gene discussed is TREM2; the disease is amyloidosis.