Furthermore, nicotinamide phosphoribosyl transferase (Nampt), a key enzyme in the salvage pathway of NAD+ synthesis in cardiomyocytes, is downregulated in the heart in response to prolonged ischemia, which contributes to a decrease in the level of NAD+ in the heart, inhibition of autophagic flux, and, consequently, increase in cardiomyocyte death [34]. This evidence concerns the gene NAMPT and ischemia.