Importantly, in non-small-cell lung carcinoma (NSCLC) tumor xenografts, the expression of a EGFR-dependent tyrosine phosphorylation mimetic BECN1 mutant resulted in reduced autophagy activity, increase of tumor growth, and resistance to TKI (tyrosine kinase inhibitor) therapy. This evidence concerns the gene EGFR and non-small cell lung carcinoma.