SQSTM1 and cancer: Accumulation of p62/SQSTM1 induced by the inhibition of autophagy has been shown to increase endoplasmic reticulum (ER) stress, DNA damage, and induce the deregulation of the nuclear factor kappa B (NF-kB) and antioxidant nuclear factor erythroid 2-related factor 2 (NRF2) pathways in many cancer cells [209,210].