PRPF3 and autosomal dominant retinitis pigmentosa: Mutations in three pre-mRNA processing factors are known to cause autosomal dominant retinitis pigmentosa: PRPF3, PRPF8, and PRPF31. Early investigation of 150 Spanish families positively identified specific point mutations in PRPF3, PRPF31, and PRPF8 [2].