In this study, we discovered the activities of IQ in the improvement of NAFLD and first revealed that effects of IQ are in the regulation of hepatic lipid accumulation, not only via AMPK pathway, but also partly via the TGF-β pathway, which is activated by KCs, and TGF-β is the key inflammatory cytokine that causes further fibrosis. The gene discussed is TGFB1; the disease is metabolic dysfunction-associated steatotic liver disease.