TNFSF10 and cancer: Our previously published data already showed an interesting synergistic effect of isofistularin-3 with TNF-related apoptosis-inducing ligand (TRAIL), an activator of the extrinsic cell death pathway [22] so that we believe the fistularin family of compounds deserves to be further explored for its synergistic anti-cancer-induction, independently of the two main apoptotic pathways.