In contrast, two recent prospective analyses have demonstrated that oophorectomy is not associated with the risk of breast cancer among women with a BRCA1 mutation, but may reduce the risk for BRCA2 mutation carriers diagnosed prior to age 50, although the latter has been based on a small number of women with a BRCA2 mutation and requires confirmation [58,59]. The gene discussed is BRCA1; the disease is breast cancer.