In A549 cells, apoptosis appears to account for a small proportion of cell death with 3.5%, 1.9%, and 7.2% cleaved caspase-3-positive cells during ZIKVAF, ZIKVCDN, and ZIKVPR infection, respectively; however, during ZIKVBR infection approximately 47% of cells stained positive for cleaved caspase-3 (Figure S2A). The gene discussed is CASP3; the disease is infection.